Neurogenomics and Neuroimaging of Developmental Disorders

Symposium and Workshops from April 30 – May 5, 2009 Dubrovnik, Croatia
Venue: Hotel Hilton and Center for Advanced Academic Studies
 

April 30, 2009 (Thursday)
Arrival of the participants
Registration at Hilton from 9.00- 18.00 h
20.00 Welcome cocktail party at CAAS

May 1, 2009 (Friday)
Registration at Hilton from 7.00 – 18.00 h

Symposium - Neurogenomics and neuroimaging of developmental disorders

Morning Sessions - I. Neurogenetic events
08.00 h Opening and Welcome Address
08.30 - 09.10 h Pasko Rakic: "Role of genes and Environment in Neuronal Migration: Relevance to developmental cognitive disorders"
09.10 - 09.50 h Orly Reiner: "LIS1 increased expression affects human and mouse brain development”
09.50 - 10.30 h Leo Chalupa: "Intrinsic circuits of developing nervous system"
10.30 - 11.10 h Daniela Prayer: “Behavioural patterns in utero”
11.10 - 11.40 h Coffee Break
11.40 - 12.20 h Gavin Clowry: “Molecular neuroanatomy of developing human cortex”
12.20 - 13.00 h Martin Staudt: "Structural plasticity of the human brain- neuroimaging approach"

13.00 LUNCH at Restaurant Mimoza

Afternoon Sessions - II. Reorganization of cerebrum in normal and lesioned brain
14.30 - 15.10 h Alan Evans: “Longitudinal Study of Normal Brain Development “
15.10 - 15.50 h Miloš Judaš: “Evolution and development of uniquely human brain: life history framework“
15.50 - 16.30 h Monique Esclapez: “Morpho-functional development of hippocampal glutamatergic and gabaergic neurons in primates”
16.30 - 17.00 h Coffee break
17.00 - 17.40 h Michael Johnston: "Perinatal origin of lesions of cortical organization after hypoxia”
17.40 - 18.20 h Ralph Freeman: "Neurometabolic coupling in cerebral cortex"
18.20 h Poster Walk I

21.00 h Working dinner for speakers only

May 2, 2009 (Saturday)
Registration at Hilton from 7.00 – 18.00 h

Morning Sessions - III. Neurogenomics and neuroimaging: Disorders in childhood and adolescents
08.00 - 08.40 h Matthew State: "Rare Variants, Autism Spectrum Disorders and Cortical Development"
08.40 - 09.20 h Nenad Šestan: “Molecular control of neuronal identity and connectivity in the cerebral cortex”
09.20 - 10.00 h Karoly Mirnics: "Schizophrenia from genetics to neuroimaging"
10.00 - 10.40 h Phillip Shaw: "Insights into Attention-deficit/hyperactivity disorder (ADHD) from structural neuroanatomic imaging"
10.40 - 11.10 h Coffee break
11.10 - 11.50 h Daniel Geschwind: “Connecting autism genes to brain”
11.50 - 12.30 h Faraneh Vargha-Khadem: "Genetic factors in language development"

12.30 h Lunch at Restaurant Mimoza

IV. Special Panel discussion:
14.00 - 15.10 h "The fetal brain from basic science to imaging"
Guests: Gustavo Malinger (moderator), Pasko Rakic, Daniela Prayer

Afternoon sessions - V. Fronto-limbic system in developmental disorders: nature and nurture
15.10 - 15.50 h Ivica Kostović “Development of fronto- limbic system in men”
15.50 - 16.30 h Harry Chugani: „Imaging of the fronto-limbic system in developmental disorders“
16.30 - 17.00 h Coffee break
17.00 - 17.40 h Diane Chugani: "Early pharmacological therapy in autisam“
17.40 - 18.20 h Alessandro Vercelli: “Functional connectivity of the insular lobe”
18.20 - 19.00 h A.S. La Mantia: "Aneuploidy, Gene Dosage and Pathogenesis in Diseases of Cortical Connectivity“

May 3, 2009 (Sunday)

Morning sessions - VI. Pharmacogenomics of developmental disorders
09.00 - 09.40 h N. Henigsberg: “Pharmacogenomics and neuroimaging in search for individualized therapy of neurodevelopmental disorders”
09.40 - 10.20 h Vlatka Mejaški-Bošnjak: “Early diagnosis of autistic spectrum disorders”
10.20 - 10.50 h Coffee Break
10.50 - 11.20 h Mario Vukšić: "Development and plasticity of the hippocampal dentate gyrus"
11.20 - 12.00 h Zdravko Petanjek: "Massive post-adolescent circuitry reorganization in the human prefrontal cortex“

12.15 h LUNCH at Restaurant Mimoza

14.00 h  Afternoon excursion to Cavtat, valley of Konavle and watermills on river Ljuta with farewell dinner at “Konavoski dvori” for all participants

May 4, 2009 (Monday)
Registration at CAAS from 8.00 - 14.00 h

I. Technical Workshop “Advances in neurogenomic approaches” - all day satellite event
Organizer Assistant Professor Fran Borovecki - Supported by EU FP7

09.00 - 10.00 h Fran Borovečki: “Transcriptome and Cistrome Analysis in Neurodegenerative Diseases"
10.00 - 11.00 h Nenad Šestan: “Genome-wide Analysis of Regional Gene Expression and Alternative Exon Usage in the Human Brain”
11.00 - 11.30 h Coffee break
11.30 - 12.30 h Tiago Fleming Outeiro: “The Molecular Basis of Parkinson’s disease: A Chemical-Genomics Approach”

12.30  - 14.00 h Lunch

14.00 - 15.00 h Jiri Zavadil: “Integrative mRNA, microRNA and proteomic profiling - lessons from disease models“
15.00 - 16.00 h Igor Rudan: “10001 Dalmatians and the success of genome-wide association studies“

II. Parallel Event - Special Meeting of US and Croatian students - "Ph.D. Neuroscience day"
In association with Professor L. Konopka, Professor I. Kostovic and Dr. M. Bras - reflections of all symposia topics for Ph.D. education in translational neuroscience
(Morning and afternoon sessions with lunch break)

May 5, 2009 (Tuesday)
Registration at CAAS from 8.00 - 14.00 h

III. Workshop on MR Spectroscopy and working with Analyze 8.0
09.00  - 10.00 h Cortical Thickness Analysis in Pediatric Brain (Alan C.Evans)
10.00 - 11.00 h Automated 3D MRI analysis
11.00 - 11.30 h Coffee break
11.30 - 12.30 h Discussion Groups

12.30  - 14.00 h Lunch

14.00 - 15.15 h Single-Voxel Proton Magnetic Resonance Spectroscopy (Marko Radoš)
Demonstration: 1. SVS technique, 2. CSI technique (with assistance of David Ozretić and Milan Radoš)

15.15 - 16.45 h Analyze 8.0 workshop
DICOM Tool, 2-D and 3-D Image Generation, Image Data Representation and Image Processing, Image Segmentation, Image Mensuration: Region of Interest (with assistance of Lana Vasung and Marko Čuljat)